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Includes bibliographical references and index. Library of Congress Cataloging-in-Publication Data In silico technologies in drug target identification and validation / edited by Darryl LeГіn and Scott Markel. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe.

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CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For permission to photocopy or use material electronically from this work, please access () or contact the Copyright Clearance Center, Inc. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Reprinted material is quoted with permission, and sources are indicated. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 1-57444-478-6 (Hardcover) International Standard Book Number-13: 978-1-57444-478-0 (Hardcover) Library of Congress Card Number 2006005722 This book contains information obtained from authentic and highly regarded sources. In Silico Technologies in Drug Target Identification and Validation Edited byД¬RC is an imprint of the Taylor & Francis Group, an informa businessД¬RC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 В© 2006 by Taylor and Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. In Silico Technologies in Drug Target Identification and Validation, edited by Darryl LeГіn and Scott Markel Handbook of Assay Development in Drug Discovery, edited by Lisa K. G Protein-Coupled Receptors in Drug Discovery, edited by Kenneth H. Phage Display in Biotechnology and Drug Discovery, edited by Sachdev S.

Industrialization of Drug Discovery: From Target Selection Through Lead Optimization, edited by Jeffrey S. Virtual Screening in Drug Discovery, edited by Juan Alvarez and Brian Shoichet 2. In Silico Technologies in Drug Target Identification and ValidationДЄndrew Carmen Johnson & Johnson PRD, LLC San Diego, California, U.S.A.ДЎ.